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KMID : 1007520150240020681
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Food Science and Biotechnology
2015 Volume.24 No. 2 p.681 ~ p.688
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Angiotensin-I Converting Enzyme Fatty Acid Inhibitory Fractions from the Korean Melania Snail Semisulcospira coreana
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Kim Yeon-Kye
Kim You-Ah
Shin Soon-Bum
Lee Tae-Seek
Yoon Ho-Dong
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Abstract
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The angiotensin-I converting enzyme (ACE) inhibitory activity of Semisulcospira coreana was investigated. Crude CH2Cl2 and MeOH extracts showed 59.3 and 25.6% ACE-inhibitory activities at 5 mg/mL, respectively. After 2 phase separations including n-hexane, 85% aqueous MeOH, n-BuOH, and H2O, the 85% aq. MeOH fraction exhibited the highest ACE-inhibitory activity of 62.1%. The inhibitory activity of 85% aq. EtOH subfraciton 5 (merf5) partially purified using C18 reversed-phase flash chromatography was increased up to 94.6% at 0.5 mg/mL. Typical fatty acids signals observed in 1H NMR and gas chromatography analysis of merf5 and n-BuOH subfractions 6 (burf6) indicated that components of merf5 and burf6 included fatty acids. The fatty acid fractions from S. coreana act as novel ACE inhibitors.
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KEYWORD
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angiotensin-1 converting enzyme, Semisulcospira coreana, melania snail, fatty acid, angiotensin-1 converting enzyme inhibitory activity
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